Yes definately post CoA level. In fact a guild without a lot of CoA gear will have a very harsh time just with the trash unless they CoH gimp past 95% of the content.
Having killed ZiT, Hatchet, Redfang, Sisters, Tris Willow, Devlin and Roley DeFarge the named events are both novel and interesting where as getting to the encounters is downright irritating. Ok Sisters is very dull too for the vast majority of the raid.
I won't go for any of the other Vampire Hunter stuff as the focus effects are heavily melee chain class oriented (mostly ranger really) and even include a really good Fire focus, since I don't use Burst of Flame that often or need Ferocity 6 on my hat I pass